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In addition, in large-scale EMR analyses, the high cardinality and significant redundancy of diagnostic codes pose critical challenges, potentially leading to issues such as data sparsity and overfitting [7]

Research protocols involving prolonged higher-frequency use may warrant monitoring of copper and zinc balance due to the inclusion of GHK-Cu

However, the conclusions that can be drawn from the included studies are significantly limited given small sample size, limited follow-up time, and a lack of control groups

Cell studies, animal studies, and small older cohorts

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