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The authors attribute these changes to a reduction in carbohydrate oxidation while maintaining the level of oxidative enzymes in muscles during a high-intensity ergometric test under fasted conditions

Perhaps most concerning is the widespread alteration of androgen receptor gene methylation at 89 CpG sites, potentially modulating AR activity across multiple generations (87)

Measures of cholangiopathy by MRCP+ did not differ between groups

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Sex-based are both metabolism of endobiotics, representing compounds produced by the body, and also of xenobioticsthe chemical substances that are not naturally produced by the organism, such as drugs, environmental pollutants, food additives, etc