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Description

Studies found that EpCAM-low CTCs had reduced proliferation but increased migration, suggesting these cells have a higher potential for metastasis [6]

Transferrin receptor as a glycoprotein, has two subunits of 90 kDa linked by a disulfide bridge, participating in the transcytosis of cellular iron by each subunit is capable of binding to one molecule of transferrin

A small fraction is metabolized by cytochrome P450 enzymes (mainly CYP2E1) to form a reactive intermediate, N-acetyl-p-benzoquinone imine (NAPQI), which is then detoxified by conjugation with glutathione