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VEGF (vascular endothelial growth factor) induction was reported in certain models, without the transcriptional mechanism being fully dissected

15,226,227 Recent therapeutic approaches focus on aldose reductase inhibitors (ARIs), such as epalrestat and ranirestat, which have shown promise in reducing sorbitol accumulation and ameliorating neuropathic symptoms in clinical trials

By "gait" we mean a subject's manner of walking or moving on foot, which is generally characterized by a particular sequence of foot and/or leg movements