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Any defect in the components of UPP or a lack of their activity result in accumulation of -synuclein protein and subsequent aggregation leading in turn to the formation of Lewy bodies

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RM was supported by FAPERJ (Grant Numbers E-26/202.668/2018, E-26/010.002215/2019, 426342/2018-6, and 312157/2016-9) and INCT-INNT (National Institute for Translational Neuroscience)

An individuals history of obesity, chronic kidney disease, medullary thyroid carcinoma or any other family health may influence the course of treatment