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Obesity-related insulin resistance activates a glycolysispurine metabolic axis, driving precursor accumulation that remains unaddressed by current therapies (Panlu et al., 2024)

Agarwal A, Allamaneni SS

Specifically, APOC1 mitigates iron-mediated cytotoxicity by upregulating the NRF2/HO-1 axis

Zangar RC, Benson JM, Burnett VL, Springer DL (2000) Cytochrome P450 2E1 is the primary enzyme responsible for low-dose carbon tetrachloride metabolism in human liver microsomes