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The ADAGIO study examined rasagilines disease-modifying effects in a large-scale, double-blind trial

GPx reduces lipid hydroperoxides to alcohols and hydrogen peroxide to water (Lubos et al

5% due to alternative cytochrome P450 depending glutathione (GSH) conjugation pathway At high doses : Glucuronidation and sulfation pathways become saturated Cytochrome P450 dependent pathway becomes now more important.With depletion of hepatic glutathione, hepatotoxic, reactive, electrophilic metabolites are formed

These results provide important proof-of-concept for treating OA by inhibiting ferroptosis (Wang X

This may help reduce oxidative stress and improve overall health