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A distributed chemosensory circuit for oxygen preference in C

Martin-Gallausiaux C, Larraufie P, Jarry A, Bguet-Crespel F, Marinelli L, Ledue F, et al

This approach mirrors dosing strategies used for other peptides with 1216 hour half-lives, though published 5-amino-1mq pharmacokinetic data in humans remains limited

Chen B, Dragomir MP, Fabris L, Bayraktar R, Knutsen E, Liu X, Tang C, Li Y, Shimura T, Ivkovic TC, Cruz De Los Santos M, Anfossi S, Shimizu M, Shah MY, Ling H, Shen P, Multani AS, Pardini B, Burks JK, Katayama H, Reineke LC, Huo L, Syed M, Song S, Ferracin M, Oki E, Fromm B, Ivan C, Bhuvaneshwar K, Gusev Y, Mimori K, Menter D, Sen S, Matsuyama T, Uetake H, Vasilescu C, Kopetz S , Parker-Thornburg J, Taguchi A, Hanash SM, Girnita L, Slaby O, Goel A, Varani G, Gagea M, Li C, Ajani JA, Calin GA

If so, would it be better to apply a double punch approach by alternating drugs targeting different cancer cell features, rather than exploiting pulses of the same anticancer agent, or would constant exposure to lethal doses of a therapeutic regimen exert a stronger pressure on DTP plasticity, thus resulting in a prolonged effect