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The extracellular matrix (ECM) of the heart is composed primarily of twisted perimysial collagen fibers (but may also include elastin and collagen fibrils) and adhesive glycoproteins (such as fibronectin, laminin, and proteoglycans), which are arranged parallel to the long axis of the cardiac muscle

10.1016/j.cub.2006.11.042 Curr

Ethics statement The animal study was approved by The Committee on the Use of Live Animals in Teaching and Research (CULATR) of the University of Hong Kong (CULATR Ref

SGLT-is significantly reduce the risk of HF by 3040% in individuals with T2D with established or high risk of CVD according to previous large-scale RCTs, and the HF benefits exists no matter the ejection fraction is preserved or reduced

Therefore, this review aims to summarize the regulation of metabolism on inflammatory response and oxidative stress in the pathogenesis of ARDS, explain the regulatory effects of various metabolites and the mechanisms involved, and finally introduce the current potential therapeutic drugs for metabolic regulation in ARDS