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Ishii S, Iizuka K, Miller BC, Uyeda K

This process exacerbates lipotoxicity and disrupts insulin signaling in peripheral tissues

D.et al (2011)

Evolution of polypeptides by synthesizing (in vivo or in vitro) conesponding deduced polynucleotides and subjecting the deduced polynucleotides to directed evolution and expression screening subsequently expressed polypeptides