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Under control conditions, AtGSTF8 and AtGSTU19 (At1g78380) are expressed almost in the whole Arabidopsis plant, but especially in specific parts and tissues of the root, such as the stele, endodermis, epidermal atrichoblasts, lateral root cap, and root hair zone (Dixon et al

Such interventions function as hormetic stimuli that potentiate endogenous cytoprotective systems by inducing the activation and upregulation of Nrf2-dependent transcriptional programs

Metformin has indirect (insulin-dependent) and direct (insulin-independent) anticancer effects (42)

Similarly, in periodontal tissues, it induces ferroptosis in fibroblasts by activating the HIF-1/p38 Mitogen-Activated Protein Kinase pathway and enhancing HIF-1/Cyclin-Dependent Kinase 9/ Bromodomain-Containing Protein 4 interactions, leading to NCOA4-mediated ferritinophagy (Zhao et al., 2020)

It results in oxidative stress due to excessive reactive oxygen species (ROS) generation, which contributes to cell damage and death