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Conversely, a smaller safety margin has been reported in some dog species, young animals, and species with a limited production of P-glycoprotein-mediated drug efflux, with neurotoxicity developing at relatively low levels of exposure

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Collectively, these findings demonstrate that CMH@lip@Res-TCeO 2 protects neutrophils by potently inhibiting the ROS/mTOR/HIF-1 signaling axis, reducing both intracellular and mitochondrial ROS, mitigating oxidative stress, and preventing apoptosis