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Restoration of the somatotropic axis with preserved pulsatility (P 800 cumulative) Tesamorelin Chemical Identity Stabilized synthetic analogue of human GHRH (44 amino acids) Tesamorelin Clinical Tolerability Safety profile evaluated in Phase III clinical trials in humans Published Clinical Data Phase III randomized controlled clinical trials published in NEJM and JAMA 15.2% Reduction of visceral adipose tissue at 26 weeks (2 mg SC/day vs placebo) Results at 26 Weeks 18% Reduction of visceral and hepatic fat at 12 months 12-Month Results Important Notice Search Only Not intended for human consumption

Neurosci Biobehav Rev 23:11111125 Mercuri NB, Saiardi A, Bonci A, Picetti R, Calabresi P, Bernardi G, Borrelli E (1997) Loss of autoreceptor function in dopaminergic neurons from dopamine D2 receptor deficient mice

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