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Many studies suggest that small polar molecules may be able to bypass the BBB by nasal administration, indicating that the interface between the nasal cavity and the brain may be a more vulnerable part of the BBB [108]

In diabetic patients, ROS can be induced by hyperglycaemia through mitochondrial respiratory chain enzymes, including XO, NOS, and peroxidases, among others [7]

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The glutathione redox cycle plays a major role in protecting organisms from reactive oxygen species, such as hydroperoxides