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Two additional targets demonstrated modest 47% (cholecystokinin A receptor) and 38% (5-hydroxytryptamine receptor 1A) inhibition

A polymorphism, R653Q, in the trifunctional enzyme methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase/formyltetrahydrofolate synthetase is a maternal genetic risk factor for neural tube defects: report of the Birth Defects Research Group

Although low vitamin B12 levels did not have a significant predictive value for EDS, there was a significant correlation between low vitamin B12 levels and EDS in obese patients (BMI 30) (OR = 3.996, 95% CI = 1.00615.876, p = 0.039)

Macronutrient distribution and fuelling for the work required As previously discussed, sport-specific nutritional recommendations support high carbohydrate intake (612 gkgd 1 ) (Reference Thomas, Erdman and Burke16,Reference Carr, McGawley and Govus28) for endurance athletes in training and competition