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This inhibitory effect of heme on macrophage phagocytosis and chemotaxis occurs through the activation of the GTP-binding Rho family protein Cdc42 by DOCK8, a guanine nucleotide exchange factor, disrupting actin cytoskeletal dynamics (102)

While animal studies have been fundamental in elucidating the biological mechanisms underlying PTSD and the impact of exercise on oxidative stress and the HPA axis, their direct applicability to humans continues to be uncertain

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