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However, once the methylester group of pectin is hydrolyzed, it also becomes more chemically accessible and thus more susceptible to degradation by microbial enzymes such as pectate lyase (PL) and polygalacturonase (PG), leading to loosening of the cell wall structure (Wormit and Usadel, 2018)

Loss of mtDNA activates astrocytes and leads to spongiotic encephalopathy

Inform patients and caregivers of this potential interaction, educate them on the signs and symptoms of respiratory depression (including sedation)

doi: 10.1016/j.jinf.2016.09.010

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