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These actions were reproduced by human anti-GAD65 monoclonal Ab b78, which binds to an epitope similar to that recognized in SPS patients positive for anti-GAD65Ab [80, 81, 82]

Primer sequences for qPCR are listed in support data (S17)

10.3390/pharmaceutics15020451 59 PuigM

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In terms of the mitochondrial homeostasis modulated by the AMPK pathway, in addition to the NAD + /SIRT1/PGC-1/FOXO axis-induced mitigation of mitochondrial oxidative stress via ROS scavenging and mitophagy, 98 AMPK-mediated induction of p53 signaling, AMPK-mediated inhibition of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B), mTORC1, and HIF-1 signaling are directly or indirectly associated with mitochondrial health protection