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The risk that someone overdosing on opioids will have a serious adverse reaction to naloxone is far less than their risk of dying from overdose. More importantly, naloxone distribution programs have made the drug freely available to family members, caregivers, friends and even opioid users themselves, and the evidence is clear: They work, the NIDA points out: A naloxone distribution program in Massachusetts reduced opioid overdose deaths, without increasing opioid use, by an estimated 11 percent in the nineteen communities that implemented the program