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It is important to note that more recent studies indicate that AGEs at the concentrations found in diabetic sera are not the major ligand for RAGE

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10.1016/j.cell.2018.08.041 Summary Keywords GLP-1, gut microbiota, microbiome, pancreatic -cells, probiotics, single-cell transcriptomics, type 2 diabetes Citation Ruchko E, Chernysheva M, Sokolov V, Starinnov Z, Sabirov M and Vasiliev A (2026) -cell heterogeneity and molecular plasticity in type 2 diabetes: multi-omics perspectives and the role of gut microbiota

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After oral supplementation with whey protein, diabetic mice and rats have been tested for B- and T-lymphocyte functions [47]