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The primary injury is mechanical, resulting from an external force, and leads to tissue deformation, tearing of blood vessels and neuronal axons, necrotic cell death, and initiation of secondary injury processes

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To date, the only reported exception has involved cells harboring oncogenic mutations, which can acquire stem cell-like properties and give rise to organoids from villus epithelium 45,46

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Ann N Y Acad Sci (1998) 865:4714