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The firstline therapy for solar lentigines is ablative therapy with cryotherapy

Furthermore, certain proteases, including MMP-1, ADAM-17, and ADAMTS-1, facilitate the release of EGFR ligands from the cellular membrane

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Neurotransmitter and neuromodulator changes have been reported in conjunction with depressive-like behaviors in AD mouse models

Strategies could focus on protecting the crypt stem cell population or inhibiting pro-apoptotic pathways specifically activated by chemotherapy in epithelial cells, by targeting the amplification loop by inhibiting key inflammatory cytokines (e.g., anti-TNF- therapy), neutralizing ROS and preventing lipid peroxidation (antioxidants), restoring a healthy gut microbiome (probiotics, prebiotics, or fecal microbiota transplantation), or inhibiting the activity of MMPs