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It has been reported that FSP1 can protect cells from ferroptosis which is induced by GPX4 inhibition/knockout (62), as TGF1 is an important cytokine that can be secreted by glioma or/and immune cell (63, 64), and it means that FSP1 could be a nexus between glioma or/and immune cell ferroptosis

Why it matters: T1 helps regulate immune balance, supporting tolerance during implantation and early pregnancy, particularly helpful in cases of recurrent pregnancy loss or immune-related fertility challenges

This does not imply, however, that the senolytic properties of D + Q are irrelevant in cancer therapy

Pharmacognosy reviews, 4(8), 118126

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