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the most likely explanation is poor oral bioavailability at the doses tested, though no official statement was made

conducted a 20-year investigation into the link between occupational heavy metal exposure and PD and found an individual with chronic copper exposure had a two-and-a-half-fold increased risk of PD [Odds Ratio [OR] 2.49, 95% CI 1.065.89] (65)

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Food and Drug Administration, Department of Health

Furthermore, female patients with hepatolenticular degeneration (HLD) often experience reproductive dysfunction (Roseira et al., 2022