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In 65 clinical cases of neurogenic cervical spondylosis, after taking Ershiwuwei Shanhu pills orally combined with acupuncture based on the condition for one course of treatment, the pain symptoms were significantly reduced, and after two courses, the symptoms disappeared completely, and no recurrence was seen thus far (Zhang and Zhang, 2011)

Activation of these kinase domains results in the activation of multiple signaling pathways including the PI3K/Akt pathway and the Raf/MEK/ERK cascade that ultimately prevent apoptosis and promote cellular growth and survival [1]

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Since LCA5 signal at the bulge is also lost in deglutamylase mutants, a possible explanation is that hyperglutamylation leads to the loss of the bulge region, thus causing IFT components to diffuse to the distal cilium and preventing their recycling