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Description

Lancet 380 , 21972223 (2012)

The vaccine, which does not use mRNA technology but instead contains a recombinant version of a specific viral protein, as well as an adjuvant to boost immune protection, is approved under emergency use authorization

One major mediator of this event is transforming growth factor-beta (TGF-), which is secreted by the tumor stroma and participates in a paracrine signaling loop with tumor cells [19]

Other models use a co-culture of astrocytes, pericytes, neural stem cells and human induced pluripotent stem cell-derived BBB endothelial cells to improve BBB integrity [116]