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In an open-label phase II study of 20 patients with ALS, the intravenous administration of edaravone (30 mg or 60 mg/day) was shown to be safe and well-tolerated, slowing disease progression as measured by the revised ALS functional rating scale (ALSFRS-R) score during the six-month treatment period, compared with the six months before the administration of edaravone [225]

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Ablation of the ferroptosis inhibitor glutathione peroxidase 4 in neurons results in rapid motor neuron degeneration and paralysis