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Under oxidative stress and induced by excessive ROS generation, Nrf2 is released from its inhibitor Keap1, allowing its translocation into the nucleus (Kasprzak et al., 2020), where it binds to the antioxidant response element (ARE) present in the DNA sequence of numerous antioxidant enzymes like glutathione-S-transferase, -glutamyl cysteine synthetase (glutamate cysteine ligase), heme oxygenase 1, and paraoxonase-1 inducing their transcription, managing the phase II response to oxidative stress (Kasprzak et al., 2020)

In summary, the Sigma-1 receptor exerts a protective effect on motor neurons by regulating ERS-related signals and provides new therapeutic targets for neuroprotection after SCI (Figure 5)

[DOI] [PMC free article] [PubMed] [Google Scholar] 36.Desai R., Coxon A.T., Dunn G.P

Most antioxidants used cannot completely intercept or neutralize oxidant species, leading to a slow buildup of oxidative damage

10.1016/j.joca.2015.02.167 98 Ruiz-RomeroC.CalamiaV.MateosJ.CarreiraV.Martnez-GomarizM.FernndezM.et al (2009)