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Sirtuins and their implications in neurodegenerative diseases from a drug discovery perspective

Although the antioxidant vitamin E protects against septic death, only the administration of caspase inhibitors (Z-VAD-FMK and wedelolactone), but not other cell death inhibitors (ferrostatin-1 or necrostatin-1) prevents septic death in gpx4 Mye -/- mice [33]