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Some patients report temporary fatigue, headache, or mild GI discomfort in the first 24 to 48 hours following an injection, particularly with their first dose

The Role of Vitamin B12 in Nerve Health Vitamin B12 plays a central role in the health and function of the nervous system

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Conversely, some studies show that a deficiency in vitamin B12 may cause appetite loss, potentially leading to weight loss if left untreated ( If youre low or deficient in B12, your healthcare provider will likely recommend oral vitamin B12 supplements or injections to increase your blood levels ( summary Low levels of vitamin B12 can cause megaloblastic anemia, which is characterized by shortness of breath, headaches, and fatigue