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4.3 The GCH1-BH4 system Recent studies reveal that GCH1-mediated BH4 metabolism controls lipid peroxidation during erastin-induced ferroptosis

Wiley et al., 2021)

Homocysteine levels are often elevated in people with MTHFR variants, especially the homozygous MTHFR C677T

These findings also underscore the antioxidant and anti-inflammatory properties of melatonin, highlighting the need for further research to elucidate optimal dosing strategies and long-term clinical outcomes