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Immunofluorescence assays further revealed a marked increase in GABA signal intensity ( + 38% 360.1) associated with elevated neuronal SMN (~1-fold increase) in SMA + NUS samples compared to SMA CTRLs ( Fig.7bd)

Subcutaneous injection delivers consistent plasma concentrations regardless of digestive state, though fasted administration still improves uptake by 2530% due to reduced amino acid competition

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