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Once in the cytoplasm, it binds and stabilizes KEAP1, thus interfering with NRF2 stabilization

10.1055/a-1956-9313 Drug Res (Stuttg)

Among these genes, only GGCT expression was significantly elevated in tumor tissues compared to normal tissues both in HCC and PCa, whereas other genes (GCLC, GCLM, GGT1, and others) showed no significant increase (Fig

RNAi (siRNA and microRNA) RNA interference (RNAi) is a fundamental cellular regulatory mechanism that can specifically block the expression of target genes at the transcriptional and translational levels through various pathways [11]