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13, 20, 26, 27, 48, 70, 71, 72 They are actively taken up into the brain 73 and can affect diverse physiological processes such as cell signaling, 71 neurotransmitter synthesis and release, 70 mitochondrial function, 20 lipid metabolism, 13, 74 immune function, 75 cellcell interactions 76 and gene expression

Pyroptosis is particularly pronounced in SIC as it can amplify inflammatory responses, resulting in tissue damage and organ dysfunction (52)

Rickets is rare, and children with a mild vitamin D deficiency may only experience weak or sore muscles

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The major contribution of this study is the strengthening of evidence to support the control of patients with pyroglutamic acidosis, in addition to proposing PyroGlu as a way to measure oxidative stress