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They received 50, 150, or 300 mg canakinumab, or placebo as subcutaneous injections every three months for a median of 3.7 years

(NOTE: The results were replicated in a separate study using a different NNMT inhibitor, also observing the normalization of tolerance to glucose and increased insulin sensitivity) Already, were seeing some strong interest in using 5-Amino 1MQ to treat obesity and other metabolic diseases in US veterans