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The acyl-CoA undergoes sequential -oxidation, generating acetyl-CoA that enters the tricarboxylic acid (TCA) cycle for energy production or converts to ketone bodies in hepatic mitochondria ( Building on these mechanistic insights, Clinical observations support carnitine's metabolic relevance in fatty liver disease, as NASH patients show significantly reduced serum L-carnitine levels compared with healthy controls ( Preclinical investigations consistently demonstrate that L-carnitine supplementation ameliorates metabolic disturbances in experimental NAFLD/NASH models

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doi:10.2903/j.efsa.2021.6577 [DOI] [PMC free article] [PubMed] [Google Scholar] 24.Carbone M, Pentenero M, Carrozzo M, Ippolito A, Gandolfo S

Crucially, with the FPT, a set of cancer biomarkers widely considered as being diagnostically informative can confidently be identified, together with their metabolite concentrations

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