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Moreover, repetitive static exercise (RSE) can be considered as a similar condition to partial ischemia/reperfusion, which may protect the tissues against oxidative stress (Zuo et al., 2013)

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Metformin, an AMPK-specific agonist, induces autophagy but also induces other signaling pathways, such as the Hedgehog [165] and ROS/JNK [166] signaling pathways, leading to off-target effects

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