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The pentose phosphate pathway is the only source of NADPH in red blood cells, and the major function of NADPH in this cell type is to maintain the tripeptide glutathione (GSH) in its reduced state, which is needed to detoxify reactive oxygen species (Figure 3)

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During menopause, the decline in estrogen levels can impair dopaminergic signaling, which may contribute to reduced motivation, feelings of anhedonia, and a general decline in cognitive flexibility [49,50,51]

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Its therapeutic applications have been investigated in cardiovascular diseases (Wang et al., 2020