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Neutrophil-mediated inflammatory responses are considered to play key roles in COPD pathogenesis ( Currently, COPD treatment mainly includes bronchodilators, inhaled corticosteroids, and phosphodiesterase-4 inhibitors, but these therapeutic approaches have relatively limited effects on neutrophil-mediated inflammation (Wedzicha et al., 2016)

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doi: 10.1002/hep.28813

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Once the receptor binds to the ligand, the body will have different responses through the formation of the complex [108, 109]