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For example, global inhibition of lactate production prevented remyelination in the corpus callosum after experimental demyelination in mice (~3-months-old), while OPC-rich primary cell cultures displayed heightened differentiation when lactate was added to the glucose medium (Ichihara et al., 2017)

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e , Top, volcano plot showing relative fold change (log 2 ) in ER-metabolite abundance versus log 10 (P value) from ER-tag HEK293T cells treated with thapsigargin compared to untreated