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Mechanistically, organophosphate hydrolases (OPH/phosphotriesterases) catalyze hydrolysis of PO/PS/PF bonds in organophosphates

Photomutagenic properties of chlorinated phenothiazine derivatives are attributed to induction of UV-A radiation dechlorination followed by formation of the promazyl radical which binds covalently to the DNA molecule (Gocke 1996)

Rapid DNA binding by nuclear factor kappa B in hepatocytes at the start of liver regeneration Cell Growth Differ 1995 6 : 417427 Iimuro Y, Nishiura T, Hellerbrand C, Behrns KE, Schoonhoven R, Grisham JW, Brenner DA

c.HuangL.et al (2021)

Future research must further elucidate the molecular pathways underlying cardiotoxicity, identify sensitive early biomarkers, and advance green chemistry principles