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However, in our hands Tm SAHH, as well as the other thermophilic enzymes, was enzymatically active without previous thermal activation

Pharmacokinetics and drug-likeness of antidiabetic flavonoids: Molecular docking and DFT study

Similar to PROTAC 51 , PROTAC 52 exhibits robust cytotoxic activity against several FLT3-ITD mutant AML cells (IC 50 = 1.66 nM) by inducing a marked UPS-dependent degradation of the FLT3-ITD protein (DC 50 = 41.35 nM)