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Oral mucosal melanotic naevus (naevomelanocytic naevus) Broadly, the term oral naevus refers to a congenital or acquired melanotic pigmentation of the oral mucosa brought about by abnormal excessive accumulation of melanocytes/naevomelanocytes at the junction of the epithelium and the lamina propria or in the lamina propria [34]

So can chemical signals that act on melanocortin receptors in the skin

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To preserve the stability and integrity of peptides, it is recommended that they should be kept out of direct sunlight and heat in a dry, cool location