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Melatonin may cause drowsiness or sleepiness, do not take when driving or operating heavy machinery, or consuming alcohol

For the complex relationship between TMAO and its metabolic precursors and chronic cardiovascular disease, more rigorous experimental protocols need should be designed to eliminate the interference of different precursor metabolites

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The function of TMAO in causing endoplasmic reticulum (ER) stress and insulin resistance in diabetes is well-documented, with TMAO levels greater in type 2 diabetics