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Over-loss and muscle pooled SURMOUNT, BMI below 22 reached by about 7% (as early as week 12), toward about 15% by week 88 in the longest trial, clinical underweight under 0.4% (Almandoz 2026)

This class of symptomatic treatments is widely referred to as antiepileptic drugs (AEDs) (Orrego-Gonzlez et al

Bead pools were resuspended in BSS (500 mM Tris-HCl pH 7.5, 1.5 M NaCl, 50 g/L BSA) and incubated in absence or presence of 10 nM TCEs at 37 C for varying amounts of time, as reported in the figures (typically 24, 8, 4, 2, 1, 0.5, 0.25 h)

& Young, L

This positive feedback loop reinforces metabolic symbiosis between cancer cells and other components of the TME