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Vitamin B12 can help prevent premature greying

[312] Consumption of coffee and tea, particularly 2-3 cups of coffee and more than 4 cups of tea per day, is associated with increased macular retinal nerve fiber layer (mRNFL) thickness, suggesting potential neuroprotective effects that warrant further investigation into causal links and mechanisms

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More serious but less common risks include pancreatitis, gallbladder disease, acute kidney injury (often secondary to dehydration from gastrointestinal effects), and hypoglycaemia when used with insulin or sulphonylureas

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