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CKD disrupts the gut microbial equilibrium, establishing a feedback loop that exacerbates disease progression ( Figure 2 ) [24, 33, 65]

Similar content being viewed by others Introduction Non-alcoholic fatty liver disease (NAFLD) includes a spectrum of liver diseases ranging from simple steatosis (accumulation of triglyceride (TG) inside hepatocytes) to non-alcoholic steatohepatitis (NASH), which is defined as the presence of hepatic steatosis and inflammation along with hepatocyte death

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474 At week 8, patients with moderate to severe UC treated with 45 mg upadacitinib showed significant improvement, with 46% reporting no intestinal urgency and 38% reporting no symptoms of abdominal pain