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Indeed, it has been shown that the acetylation of SDHA causes its deactivation, which in turn leads to activation of H3K4me3 activation, accompanied by change in tumor-specific gene expression [40]

The conformational flexibility of TM11 appears to be linked with substrate recognition, with R471 (responsible for carnitine coordination) located near the midpoint of this helix, between the two segments that bend during the transition between inward-facing and occluded conformations

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The disruption of the bottom-up limiting processes may allow blooms of dinoflagellates, including harmful ones, to develop (Almeda et al., 2018)