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It showed that even ingredients designed to improve appearance can, under certain conditions, target melanocytes and cause long-lasting pigment loss

This activates 5-AMP-activated protein kinase (AMPK) to upregulate the glycolysis of 6-phosphofructo-1-kinase (PFK1), which compensates for the loss of mitochondrial ATP and maintains the mitochondrial membrane potential (Almeida et al., 2004)

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