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Immune cells that mediate the initiation and progression of inflammatory responses consequently represent promising therapeutic targets for intervention in age-related immune dysfunction

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Comparing to a topical application of the solution containing the same amount of hydrophilic red dye, great improvement in intra-epidermal and intradermal delivery could be achieved via DDMNs (comparing the left and the right panels in Fig

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One of the key challenges is the compensatory upregulation of other enzymes, such as TDO2, which can maintain kynurenine production in the presence of IDO1 inhibitors ( Figure 1B ) (38)